Considering that the development of androgenetic alopecia depends on two factors: genetics + male hormone (androgen).

Dutasteride with vitamins works by reducing the amount of androgens that reach the hair follicle, specifically DHT (Dihydrotestosterone).

It achieves this by inhibiting 5-alpha-reductase type 2, an enzyme responsible for the transformation of testosterone into Dihydrotestosterone in the hair follicle, thus producing less DHT.

As there are 2 enzymes responsible for the transformation of testosterone to Dihydrotestosterone: 5-alpha-reductase type I and 5-alpha-reductase type II, and the blocker only acts on type II, there will always be DHT that continues to act on the hair follicle and other areas of the body.

The results will be better in those individuals who have been losing hair for a shorter period of time.

Since it is impossible to know in advance the degree of benefit that can be expected from the drug for a specific person, they should take the medication for at least 6 months. After this period, the continuation or discontinuation of the treatment will be evaluated.

Medications that act through different mechanisms generally have a combined administration for their effects.

The blocker of testosterone’s effect on hair, Dutasteride, is a drug that is generally well-tolerated. Most of the side effects are not common, and if they do appear, they tend to diminish with prolonged use.

In only 2% of cases, it may cause a decrease in libido (sexual desire) and ejaculatory volume. Generally, with continued use of the medication, these issues decrease or reverse upon discontinuation.

At the beginning of treatment, there may be an initial increase in hair shedding, but this is transient and should not be a reason to stop the treatment.

One downside is that when it is stopped, any gains achieved will be lost, so it is a drug that generally needs to be taken for life.

The drug has passed all tumor induction controls and is generally well-tolerated.

Its use in fertile women is completely contraindicated as it could cause alterations in the sexual development of the fetus.

In women on contraception or menopause, it is well-tolerated and can help slow down hair loss, although the indicated dosage is slightly higher than in men. Its use in women does not, under any circumstances, cause virilization in women.

Naturally, when tissue ruptures, (a cut, for example), so-called platelet aggregation occurs, in other words, the platelets clump together to form a stopper (“platelet stopper”) that closes the wound and prevents blood loss.

During aggregation or having contact with the connective tissue, the membrane cells of the platelet are activated by releasing the contents of their Alpha Granules, these are growth factors. When these growth factors come together with cell membrane receptors, the cell is either activated or inhibited in its functions.

There are several types of growth factors, each of them responsible for a function in different tissues. Thus, growth factors regulate and therefore play a majorly important role in appearance, production diminishing with age and becoming less active

On the other hand, growth factors intervene as external cell cycle control:
They stimulate cell migration and proliferation by increasing the rate of mitosis (Cell multiplication) of all cells with suitable receptors, cell differentiation and apoptosis (programmed cell death). They also increase cell metabolism, by stimulating cellular processes for the regeneration of tissue and wound healing (repair, remodeling).
With the skin, they stimulate the processes of division, migration and differentiation of epithelial cells, there is also the increased cellular synthesis of keratinocytes, endothelial cells, fibroblasts, monocytes and macrophages. In addition, they stimulate the synthesis of collagen, elastin and proteoglycans.

They have an important angiogenic role (The formation of new blood vessels).

Takakura et al. demonstrated that Platelet-Derived Growth Factor (PDGF) signals are related to epidermal-follicle interactions and mesenchymal (embryonic tissue) interactions necessary for hair canal formation and dermal mesenchymal growth. In 2001, Yano et al. identified Vascular Endothelial Growth Factor (VEGF) as the most important mediator of hair follicle growth and its cycles, providing the first direct evidence that improved follicular vascularization promotes growth and increases the size of the follicle and hair strand.

Physiologically, the hair follicle provides a certain number of hairs throughout a person’s life. As the follicle becomes depleted, the caliber and color of the hair diminish, and miniaturized hair, which is finer and lighter in color, becomes evident.

Considering that “when the follicle has miniaturized to the point of not being observable to the naked eye, it still has the potential to re-transform and generate long hair strands,” and that “the hair is practically composed of the same type of stem cells in the bulge area (the area of the follicle with the potential to form a new hair), then it should be possible for the miniaturized hair to reverse.”

In other words, even though the hair appears miniaturized and fine, it still retains the potential to be reactivated and regenerate into long, healthy hair strands under the right conditions.

First, there is the extraction of approximately 16 cc of the patient’s blood. It is then processed by centrifugation to get 8cc of Rich Plasma in Platelets.
It will then be applied in the form of multiple micro-punctures (nappage), by way of mesotherapy and filling out wrinkles where needed to create volume.
A thin film of PRP will be left on the face for 10 minutes to act topically, further enhancing the appearance of the skin.

The results of the study conducted by Greco et al. revealed a thickening of the hair strand by 9.7% at 4 months and 6.1% at 8 months.

Approximately 30 minutes between extraction and infiltration of PRP in the tissue.

Since micro punctures are performed, slight discomfort may occur but can be minimized with the topical application of anesthetic cream (EMLA) beforehand (20 minutes).

Without any difference compared to how it entered.

Although, in general, there is no discomfort, on some occasions, a very slight sensation may be noticed when touching the injected area for a couple of days.

Generally, the effect starts to be noticeable after one month.

When starting the treatment, it is advisable to have 3 sessions in 3 months, which means 1 session per month.